反应详情

6-Chloro-4-(methylamino-phenyl-methyl)-pyridin-3-ylamine (100 mg, 0.323 mmol) and 1,1′-carbonyl-diimidazole (100 mg, 0.586 mmol) are stirred in THF (5 mL) at room temperature for 1.5 hours. The reaction mixture is added to water and the aqueous phase extracted with dichloromethane. The organic phase is dried over magnesium sulfate. The solvent is removed in vacuo and the residue purified by column chromatography on silica gel using a dichloromethane/methanol gradient. The product fractions are evaporated to dryness to provide the desired compound.

1. extractionthe aqueous phase extracted with dichloromethane
2. dry with materialThe organic phase is dried over magnesium sulfate
3. customThe solvent is removed in vacuo
4. customthe residue purified by column chromatography on silica gel using a dichloromethane/methanol gradient
5. customThe product fractions are evaporated to dryness