Water → 6-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one

HRID 1497766Notes

Reaction equation

HRID 1497766 reaction equation
[Br:1][C:2]1[C:3]([CH3:19])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[C:5](Cl)=[N:6][CH:7]=1.O.[NH2:21][NH2:22].O.[O:24]1[CH2:29]COCC1>C1COCC1>[Br:1][C:2]1[C:3]([CH3:19])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[C:5]2[N:6]([C:29](=[O:24])[NH:21][N:22]=2)[CH:7]=1

Participants

6

Conditions

Temperature
90 °C

Procedure

A solution of 5-bromo-2-chloro-4-methyl-3-(3-trifluoromethyl-phenyl)-pyridine (Int. 14, 176 mg, 0.503 mmol) and hydrazine hydrate (2.5 mL, 52 mmol) in dioxane (5 mL) was heated at 90° C. for 7 hrs. A further quantity of hydrazine hydrate (2.5 mL) was added and the reaction mixture heated at 90° C. for 18 hrs and then at 100° C. for 5 days. The reaction mixture was cooled then poured into water (15 mL) and extracted with EtOAc (3×15 mL). The combined organic extracts were dried (Na2SO4), filtered and evaporated in vacuo to afford a yellow solid. The solid was dissolved in THF (2 mL) and then N,N′-carbonyldiimidazole (375 mg, 2.31 mmol) was added and the reaction mixture stirred at RT for 22 hrs before being concentrated in vacuo. The resultant residue was purified by flash chromatography, eluting with a gradient of 0-100% EtOAc in cyclohexane to give the title compound as a tan solid (184 mg).

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with EtOAc (3×15 mL)
  3. dry with materialThe combined organic extracts were dried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customto afford a yellow solid
  7. concentrationbefore being concentrated in vacuo
  8. customThe resultant residue was purified by flash chromatography
  9. washeluting with a gradient of 0-100% EtOAc in cyclohexane

Sources & evidence

ORD record
ord-339bbd9c97d0497c9cf1067a0fea0c53
Source dataset
uspto-grants-2015_12
Patent number
US09199984B2

Reaction notes

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