Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → 3-isopropyl-1-methyl-1H-1,2,4-triazol-5(4H)-one

HRID 1498060Notes

Reaction equation

HRID 1498060 reaction equation
[C:1]([NH:6][N:7]([CH3:11])[C:8]([NH2:10])=[O:9])(=O)[CH:2]([CH3:4])[CH3:3].C12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O>C(OC(=O)C)C>[CH:2]([C:1]1[NH:10][C:8](=[O:9])[N:7]([CH3:11])[N:6]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 582047742-Isobutyryl-1-methylhydrazinecarboxamide

Product 1

HCID 1360579243-isopropyl-1-methyl-1H-1,2,4-triazol-5(4H)-one

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Isobutyryl-1-methylhydrazinecarboxamide was cyclized with 10-camphorsulfonic acid at reflux in ethylacetate to give 3-isopropyl-1-methyl-1H-1,2,4-triazol-5(4H)-one.

Sources & evidence

ORD record
ord-d1f9079006f94338925375e61b63ae24
Source dataset
uspto-grants-2015_12
Patent number
US09198918B2

Reaction notes

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