Hydrochloric Acid → HCID 68641848, compound

HRID 1498925Notes

Reaction equation

HRID 1498925 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[C:12]([C:15]([O:17]C)=[O:16])[NH:13][N:14]=2)=[C:6]([O:19][CH3:20])[CH:5]=1.Cl>C(O)C>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[C:12]([C:15]([OH:17])=[O:16])[NH:13][N:14]=2)=[C:6]([O:19][CH3:20])[CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68642081HCID 68642081, compound

Product 1

HCID 68641848HCID 68641848, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (1 ml) and a 20% sodium hydroxide aqueous solution were mixed with methyl 5-(4-chloro-2-methoxyphenyl)-2H-pyrazole-3-carboxylate (100 mg) obtained in the Step 18-1-2, and the mixture was heated under reflux. After one hour, the mixture was allowed to cool to a room temperature and acidified with 2-N hydrochloric acid. The precipitated crystal was separated by filtration to give the title compound (90 mg, 95%).

Workup

  1. customobtained in the Step 18-1-2
  2. temperaturethe mixture was heated
  3. temperatureunder reflux
  4. customThe precipitated crystal was separated by filtration

Sources & evidence

ORD record
ord-aec7ffbcc74b4ac8b82762a3e3e78cce
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

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