Levulinic Acid → 3-Bromo-4-oxopentanoic acid

Concentrated hydrochloric acid (20 ml) was added to 4-oxopentanoic acid (5.0 g), and bromine was added dropwise thereto at −15° C. The mixture was stirred at a room temperature. After 4 hours, the reaction solution was poured into ice water (45 ml). The reaction solution was subjected to extraction with ethyl ether, and the organic layer was washed with a saturated saline solution, dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure to give the title compound (7.06 g, 84%).

1. additionwas added dropwise
2. customat −15° C
3. extractionThe reaction solution was subjected to extraction with ethyl ether
4. washthe organic layer was washed with a saturated saline solution
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under a reduced pressure

ORD record

ord-760210fe97d9471d9a17f4828b47d075

Source dataset

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09200008B2