反应详情

Methyl 6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxylate (80.0 mg, 0.255 mmol) was dissolved in THF (0.3 mL) and MeOH (0.3 mL), then 1.0 M aq. NaOH (1.28 mL, 1.28 mmol) was added. The reaction mixture was stirred at room temperature for 50 min., then neutralized with HCl (12 M) to pH=7 and concentrated under reduced pressure to remove all the solvents. The residue was dissolved in THF, dried, filtered and concentrated under vacuum to give the sub-title compound as a white powder (42 mg, 55%). LCMS calc. for C13H9F3NO2S (M+H)+: m/z=300.0. Found: 300.2.

1. concentrationconcentrated under reduced pressure
2. customto remove all the solvents
3. dissolutionThe residue was dissolved in THF
4. customdried
5. filtrationfiltered
6. concentrationconcentrated under vacuum