反应详情

Methyl 6-[2,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoropyridine-2-carboxylate (78.0 mg, 0.226 mmol) was dissolved in THF (0.2 mL) and MeOH (0.2 mL), and 1.0 M aq. NaOH (0.90 mL, 0.90 mmol) was then added. The reaction mixture was stirred at room temperature for 40 min. The solution was then neutralized with HCl (12 M) to pH=7 and concentrated under reduced pressure to remove all the solvents. The residue was dissolved in THF and MeOH, dried, filtered and concentrated under reduced pressure to give the sub-title compound as a white powder. LCMS calc. for C13H9F3NO4S (M+H)+: m/z=332.0. Found: 332.2.

1. concentrationconcentrated under reduced pressure
2. customto remove all the solvents
3. dissolutionThe residue was dissolved in THF
4. dry with materialMeOH, dried
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure