反应详情

A mixture of 3-amino-4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate (0.010 g, 0.022 mmol), 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylic acid (0.0082 g, 0.026 mmol), HATU (0.022 g, 0.057 mmol) in DMF (0.06 mL) and DIPEA (0.011 mL, 0.065 mmol) was stirred at room temperature for 1 h. The mixture was quenched with 1N NaOH solution and extracted with EtOAc. The organics were combined, dried over Na2SO4 and concentrated to give the sub-title compound as a brown solid. LCMS calc. for C36H40F6N5O6 (M+H)+ m/z=752.3. found: 752.0.

1. customThe mixture was quenched with 1N NaOH solution
2. extractionextracted with EtOAc
3. dry with materialdried over Na2SO4
4. concentrationconcentrated