反应详情

A mixture of cyanuric chloride (0.15 g, 0.84 mmol) and N,N-dimethylformamide (0.065 mL, 0.84 mmol) was stirred at room temperature for 10 min and then a solution of 3-chloro-6-ethoxy-N-ethyl-5-(1-hydroxyethyl)-2-methylbenzamide (0.16 g, 0.56 mmol) in methylene chloride (3.1 mL) was added and the reaction was stirred at room temperature overnight. The mixture was diluted with methylene chloride, washed with water, concentrated and purified on silica gel (eluting with 0 to 40% EtOAc in hexanes) to give the desired product (0.13 g, 76%). LCMS calculated for C14H20Cl2NO2 (M+H)+: m/z=304.1; Found: 304.1.

1. stirringthe reaction was stirred at room temperature overnight
2. washwashed with water
3. concentrationconcentrated
4. custompurified on silica gel (eluting with 0 to 40% EtOAc in hexanes)