反应详情

The Carbopol 934P and Poloxamer 407 (BASF Corp.) are first suspended in the TRIS HCl buffer (0.1 M) and the components are mixed under agitation overnight at 4° C. to ensure complete dissolution. The methylparaben is added and further stirring allowed until complete dissolution is observed. Ganciclovir sodium is mixed in while maintaining stirring to produce a 2.0% ganciclovir mucoadhesive, thermoreversible gel formulation. The mixture is maintained below room temperature until use.

1. additionthe components are mixed under agitation overnight at 4° C.
2. dissolutiondissolution
3. dissolutionallowed until complete dissolution
4. temperaturewhile maintaining
5. stirringstirring