Sodium Sulfide → HCID 178494291, compound

HRID 1500105Notes

Reaction equation

HRID 1500105 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([O:19][CH3:20])[N:3]=1.[S-2:21].[Na+].[Na+]>CN(C=O)C>[OH:16][C:13]1[CH:14]=[CH:15][C:10]([C:6]2[C:7]([C:8]#[N:9])=[C:2]([SH:21])[N:3]=[C:4]([O:19][CH3:20])[C:5]=2[C:17]#[N:18])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14804Sodium SulfideHCID 136337800HCID 136337800, compound

Product 1

HCID 178494291HCID 178494291, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.3 g (4.550 mmol) of 2-chloro-4-(4-hydroxyphenyl)-6-methoxypyridine-3,5-dicarbonitrile are initially charged in 10 ml of DMF, 426 mg (5.460 mmol) of sodium sulphide are added and the mixture is stirred at room temperature overnight. The reaction mixture is reacted further without any further purification.

Workup

  1. customThe reaction mixture is reacted further without any further purification

Sources & evidence

ORD record
ord-091c112945a04f759c182a164825fd34
Source dataset
uspto-grants-2015_12
Patent number
US09205077B2

Reaction notes

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