反应详情

n-PentylMgBr (29 mL, 58 mmol, 2 M/ether) was added to a 0° C. solution of 4-bromobenzaldehyde (9.953 g, 54 mmol) in THF (100 mL). After 1 h, the reaction was quenched by addition of 200 mL saturated ammonium chloride solution. The resulting mixture was extracted with ethyl acetate (3×100 mL) and the combined ethyl acetate solution was dried (Na2SO4), filtered and evaporated. Purification of the residue by flash chromatography on silica gel gave 4 (10.501 g, 76%).

1. customthe reaction was quenched by addition of 200 mL saturated ammonium chloride solution
2. extractionThe resulting mixture was extracted with ethyl acetate (3×100 mL)
3. dry with materialthe combined ethyl acetate solution was dried (Na2SO4)
4. filtrationfiltered
5. customevaporated
6. customPurification of the residue by flash chromatography on silica gel