反应详情

Sodium hydride (7 mg, 0.17 mmol) is added to 2-(5-bromopyridin-2-yl)acetonitrile (300 mg, 0.15 mmol) in THF at −5° C. After 30 minutes methyl iodide is added (56 μL, 1.5 mmol) and the mixture warmed to r.t. After stirring for 4 hours, the mixture is partitioned between brine and methylene chloride. The organics were separated, dried over magnesium sulfate and the solvent removed under reduced pressure. The crude material is purified by silica gel chromatography to give the title compound (128 mg): LCMS [M+H] 196.0.

1. customthe mixture is partitioned between brine and methylene chloride
2. customThe organics were separated
3. dry with materialdried over magnesium sulfate
4. customthe solvent removed under reduced pressure
5. customThe crude material is purified by silica gel chromatography