Ethyl chloroacetate → HCID 131734275, compound

HRID 1500405Notes

Reaction equation

HRID 1500405 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[NH:14][N:13]=[N:12][N:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.Cl[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][N:11]1[C:10]([C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][O:3][C:4]=3[CH:9]=2)=[N:14][N:13]=[N:12]1)[CH3:21]

Participants

5

Reactant 3

HCID 7751Ethyl chloroacetateHCID 11430Potassium CarbonateHCID 178419808HCID 178419808, compound

Product 1

HCID 131734275HCID 131734275, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 5-(1,3-benzodioxol-5-yl)-1H-tetrazole (10 mmol), ethyl chloroacetate (10 mmol) and potassium carbonate (15 mmol) in dry acetone (100 mL) was refluxed for 24 h. The reaction mixture was filtered, the solvent was distilled. The crude ester thus obtained was purified by recrystallization from ethanol.

Workup

  1. temperaturewas refluxed for 24 h
  2. filtrationThe reaction mixture was filtered
  3. distillationthe solvent was distilled

Sources & evidence

ORD record
ord-60c1001a8d184328a9a4e89392fcf842
Source dataset
uspto-grants-2015_12
Patent number
US09206165B2

Reaction notes

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