Hydrochloric Acid → HCID 71767564, compound

HRID 1500508Notes

Reaction equation

HRID 1500508 reaction equation
[O:1]=[C:2]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][O:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)=[CH:12][N:11]=1)[CH2:3][CH2:4][C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>O1CCCC1.CO>[O:1]=[C:2]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][O:17][CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)=[CH:12][N:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 117778016HCID 117778016, compound

Product 1

HCID 71767564HCID 71767564, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methyl 4-oxo-4-({5-[(4-phenylphenyl)methoxymethyl]-2-pyridyl}amino)butanoate (0.168 g) was dissolved in a mixed solvent of tetrahydrofuran (3 mL) and methanol (1 mL). To the solution, an aqueous sodium hydroxide solution (1 M, 0.830 mL) was added at room temperature, and the mixture was stirred for 1 hour. Hydrochloric acid (1 M, 0.830 mL) was added to the reaction solution, and the mixture was stirred at 0° C. The resulting suspension was filtered, and the product collected by filtration was washed with water and dried under reduced pressure to obtain the title compound (0.150 g).

Workup

  1. stirringthe mixture was stirred at 0° C
  2. filtrationThe resulting suspension was filtered
  3. filtrationthe product collected by filtration
  4. washwas washed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-089f98b2b8954a70923a66ad80af6942
Source dataset
uspto-grants-2015_12
Patent number
US09206168B2

Reaction notes

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