Hydrochloric Acid → 4-Chlorobenzo(b)thiophene-2-carboxylic Acid

HRID 1500540Notes

Reaction equation

HRID 1500540 reaction equation
[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([O-:13])=[O:12])[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Na+].Cl>O>[C:11]([C:8]1[S:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[C:10]=2[CH:9]=1)([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71239220HCID 71239220, compound

Product 1

HCID 38545164-Chlorobenzo(b)thiophene-2-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium 4-chlorobenzo[b]thiophen-2-carboxylate (2.40 g) was dissolved in water (33 ml) at 60° C. Concentrated hydrochloric acid (1.3 ml) was added to the solution at the same temperature, and the resulting mixture was stirred. The precipitated crystals were collected by filtration, washed with water, and then dried to obtain 2-carboxy-4-chlorobenzo[b]thiophene.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-5fd690c779a343f2a14cd56f101b306e
Source dataset
uspto-grants-2015_12
Patent number
US09206169B2

Reaction notes

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