Hydrochloric Acid → 3-Propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

HRID 1500609Notes

Reaction equation

HRID 1500609 reaction equation
C(OC([N:8]1[CH2:22][CH2:21][C:11]2[NH:12][C:13](=[O:20])[N:14]([CH2:17][C:18]#[CH:19])[C:15](=[O:16])[C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:23]>C(OCC)(=O)C.C(O)C>[ClH:23].[CH2:17]([N:14]1[C:15](=[O:16])[C:10]2[CH2:9][NH:8][CH2:22][CH2:21][C:11]=2[NH:12][C:13]1=[O:20])[C:18]#[CH:19]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 866631126-(Tert-butoxycarbonyl)-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione

Product 1

HCID 866631133-Propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

6-(tert-Butoxycarbonyl)-3 propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione (1.0 g) was suspended in 4 N hydrochloric acid in ethyl acetate (10 ml) and the resultant mixture was stirred at room temperature for 3 hours. A precipitate was obtained by filtration and dissolved in ethanol and the solvent was distilled away under reduced pressure. This was repeated three times to obtain the titled compound (790 mg) as a colorless amorphous substance. The resultant compound was subjected to a next reaction without further purifying.

Workup

  1. customA precipitate was obtained by filtration
  2. distillationthe solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-e0c46780a1d84cf2858615f99e96fa34
Source dataset
uspto-grants-2015_12
Patent number
US09206173B2

Reaction notes

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