Hydrochloric Acid → 3-Methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

HRID 1500611Notes

Reaction equation

HRID 1500611 reaction equation
C(OC([N:8]1[CH2:21][CH2:20][C:11]2[NH:12][C:13](=[O:19])[N:14]([O:17][CH3:18])[C:15](=[O:16])[C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[CH3:18][O:17][N:14]1[C:15](=[O:16])[C:10]2[CH2:9][NH:8][CH2:21][CH2:20][C:11]=2[NH:12][C:13]1=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 666858106-(Tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione

Product 1

HCID 666886833-Methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-(tert-Butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione (1.0 g) was suspended in 4 N hydrochloric acid in ethyl acetate (10 ml) and the resultant mixture was stirred at room temperature for 3 hours. The reaction solution was distilled away under reduced pressure. To the residue, methanol was added and the solvent was distilled away under reduced pressure. This was repeated three times to obtain the titled compound (790 mg) as a white powder. The resultant compound was used in a next reaction without further purifying.

Workup

  1. distillationThe reaction solution was distilled away under reduced pressure
  2. additionTo the residue, methanol was added
  3. distillationthe solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-09bcf3ca4b4a4aba8b321956f8371088
Source dataset
uspto-grants-2015_12
Patent number
US09206173B2

Reaction notes

Loading…