Hydrogen Bromide → HCID 178516493, compound

HRID 1500746Notes

Reaction equation

HRID 1500746 reaction equation
Br.C[O:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]2[CH:11]=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=23)[N:5]=1>>[N:12]1[N:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]2=[C:10]([C:6]2[N:5]=[C:4]([OH:3])[CH:9]=[CH:8][N:7]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 67327927HCID 67327927, compound

Product 1

HCID 178516493HCID 178516493, compoundYield 100%

Conditions

Temperature
100 °C

Procedure

48% Aqueous hydrogen bromide (19.50 mL) was added to 3-(4-methoxypyrimidin-2-yl) pyrazolo[1,5-a]pyridine (Preparation 4a, 0.30 g, 1.32 mmol) and the resulting mixture was heated to 100° C. with stirring. After 3 hours, the mixture was cooled and the resultant precipitate was filtered and dried in vacuo to give the title compound (0.28 g, 99%) as the hydrobromide salt.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationthe resultant precipitate was filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-625c7ff4699a489280a8c607c82d84bc
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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