反应详情

To the solution of methyl 4-(1-(tetrahydrofuran-3-yloxy)ethyl)benzoate (371 mg, 1.48 mmol) in methanol (15 mL) and water (5 mL) was added lithium hydroxide hydrate (100 mg, 2.4 mmol) were add ed. The mixture was stirred at room temperature for 12 hours. Then the reaction mixture was acidified by hydrochloric acid aqueous solution (1 N) to adjust pH=6 and extracted with dichloro methane (10 mL×3). The organic layers were combined and concentrated to give 4-(1-(tetrahydrofuran-3-yloxy)ethyl)benzoic acid (311 mg, 89%)

1. additionwere add
2. extractionextracted with dichloro methane (10 mL×3)
3. concentrationconcentrated