反应详情

To the solution of methyl 4-(1-(2,4-difluorophenoxy)ethyl)benzoate (151 mg, 0.54 mmol) in meth anol/water (50 mL) was added lithium hydroxide (50 mg, 2.1 mmol), the solution was stirred at room temperature for 12 hours. Then the solution was acidified by hydrogen chloride (1 N/mol) pH to 6, extracted with dichloromethane (50 mL*3), evaporated the solvent and the residue was purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=5:1) to give 4-(1-(2,4-difluorophenoxy)ethyl)benzoic acid (127 mg, 88%)

1. extractionto 6, extracted with dichloromethane (50 mL*3)
2. customevaporated the solvent
3. customthe residue was purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=5:1)