Triethylamine → HCID 178492317, compound

HRID 1501276Notes

Reaction equation

HRID 1501276 reaction equation
[O:1]=[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][N:3]1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:12].ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.C(N(CC)CC)C.[NH2:48][CH2:49][C:50]1[C:51]([OH:59])=[N:52][C:53]([CH3:58])=[CH:54][C:55]=1[O:56][CH3:57]>ClCCl.O>[OH:59][C:51]1[C:50]([CH2:49][NH:48][C:8]([C:6]2[CH:5]=[CH:4][N:3]([CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH3:12])[C:2](=[O:1])[CH:7]=2)=[O:10])=[C:55]([O:56][CH3:57])[CH:54]=[C:53]([CH3:58])[N:52]=1

Participants

8

Reactant 5

HCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 89585074HCID 89585074, compoundHCID 178492315HCID 178492315, compound

Product 1

HCID 178492317HCID 178492317, compoundYield 28.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylic acid (97 mg, 0.40 mmol) in dichloromethane (15 mL) were added 1-Hydroxybenzotriazole (73 mg, 0.54 mmol), 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (104 mg, 0.54 mmol) and triethylamine (111 mg, 1.1 mmol). The resultant solution was stirred at room temperature for 30 minutes. Then 3-(aminomethyl)-4-methoxy-6-methylpyridin-2-ol (60 mg, 0.36 mmol) was added to the solution, and it was stirred at room temperature for 16 hours. Water (20 mL) was added to the mixture. It was extracted with dichloromethane (50 mL). The organic layer was concentrated in vacuo to provide crude product which was purified by silica gel column chromatography with dichloromethane/methanol=10:1 to afford N-((2-hydroxy-4-methoxy-6-methylpyridin-3-yl)methyl)-2-oxo-1-(1-phenylethyl)-1,2-dihydro pyridine-4-carboxamide (40 mg, 28% yield) as a white solid. 1H NMR (300 MHz, CD3OD): δ 7.56 (d, J=7.2 Hz, 1H), 7.31-7.39 (m, 5H), 6.86 (d, J=1.8 Hz, 1H), 6.60 (br, 1H), 6.25-6.30 (m, 2H), 4.41 (s, 2H), 3.91 (s, 3H), 2.31 (s, 3H), 1.76 (d, J=7.2 Hz, 3H).

Workup

  1. extractionIt was extracted with dichloromethane (50 mL)
  2. concentrationThe organic layer was concentrated in vacuo
  3. customto provide crude product which
  4. customwas purified by silica gel column chromatography with dichloromethane/methanol=10:1

Sources & evidence

ORD record
ord-6e702d24fb7b4b8f9208cc1ab131c700
Source dataset
uspto-grants-2015_12
Patent number
US09206128B2

Reaction notes

Loading…