Tetrahydrofuran → 1-[5-(1,3-Difluoro-2-methylpropan-2-yl)isoxazol-3-yl]-3-{3-[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-ylthio]phenyl}urea
Reaction equation
[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[CH3:22][O:23][c:24]1[cH:25][c:26]2[c:27]([S:39][c:40]3[cH:41][c:42]([NH2:43])[cH:44][cH:45][cH:46]3)[n:28][cH:29][n:30][c:31]2[cH:32][c:33]1[O:34][CH2:35][CH2:36][O:37][CH3:38].[CH3:47][N:48]([CH3:49])[c:50]1[cH:51][cH:52][n:53][cH:54][cH:55]1.[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[cH:8][c:9]([NH:12][C:13]([O:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)=[O:21])[n:10][o:11]1>>[F:1][CH2:2][C:3]([CH2:4][F:5])([CH3:6])[c:7]1[cH:8][c:9]([NH:12][C:13](=[O:21])[NH:43][c:42]2[cH:41][c:40]([S:39][c:27]3[c:26]4[cH:25][c:24]([O:23][CH3:22])[c:33]([O:34][CH2:35][CH2:36][O:37][CH3:38])[cH:32][c:31]4[n:30][cH:29][n:28]3)[cH:46][cH:45][cH:44]2)[n:10][o:11]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-0a390e91d15d410792ef8b58f61fdcec
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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