Hydrochloric Acid → HCID 71014370, compound

HRID 1501878Notes

Reaction equation

HRID 1501878 reaction equation
[F:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:21]>C(OCC)(=O)C>[ClH:21].[F:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67323585HCID 67323585, compound

Product 1

HCID 71014370HCID 71014370, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 4-fluoro-4-pyridin-2-ylpiperidine-1-carboxylate (0.075 g, 0.27 mmoL) in 10 mL of ethyl acetate was saturated with gaseous hydrochloric acid. After 1 hr, the mixture was concentrated in vacuo to provide 2-(4-fluoropiperidin-4-yl)pyridine hydrochloride that gave a mass ion (ES+) of 181.1 for [M+H]+

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cdd2a88f27074924a4ec01539fcd03e1
Source dataset
uspto-grants-2015_12
Patent number
US09206200B2

Reaction notes

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