反应详情

A solution of 2-(4-cyano-3-fluorophenyl)ethyl methanesulfonate (35.0 g, 144 mmol) and triethylamine (50 mL) in DCM (200 mL) was added DBU (50 mL) dropwise to at 0° C. After stirring at room temperature overnight, the solution was diluted with DCM, washed with 1 N HCl and brine, and dried over anhydrous sodium sulphate and concentrated. The residue was purified by column chromatography to give title compound.

1. washwashed with 1 N HCl and brine
2. dry with materialdried over anhydrous sodium sulphate
3. concentrationconcentrated
4. customThe residue was purified by column chromatography