Lithium Hydroxide → HCID 67518087, compound

HRID 1502133Notes

Reaction equation

HRID 1502133 reaction equation
[OH-].[Li+].[CH3:3][C:4]1[CH:9]=[C:8]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)[N:7]=[CH:6][C:5]=1[CH2:15][C:16]([O-:18])=[O:17]>C1COCC1>[CH3:3][C:4]1[CH:9]=[C:8]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)[N:7]=[CH:6][C:5]=1[CH2:15][C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86693032HCID 86693032, compound

Product 1

HCID 67518087HCID 67518087, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of lithium hydroxide (1 N, 4.75 ml) was added to a stirred mixture of [4-methyl-6-(1H-tetrazol-1-yl)pyridin-3-yl]acetate (1.00 g, 4.29 mmol) in THF (10 ml) and the mixture was stirred at room temperature for 2 h. The reaction mixture was acidified to pH ˜3-4 and extracted with EtOAc (3×). The combined organic layers were washed with brine, dried (Na2SO4), filtered and concentrated to provide title compound which was used directly: LC-MS (IE, m/z): 206 [M+1]+.

Workup

  1. extractionextracted with EtOAc (3×)
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-ca28e7d858374711b589bc6c49f964cd
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

Loading…