反应详情

A solution of methyl 2-(2-(1H-tetrazol-1-yl)pyrimidin-5-yl)propanoate (70.2 mg, 0.300 mmol) in the mixture of THF (2.6 mL)/Water (0.4 mL) was treated with sodium hydroxide (1M, aqueous) (450 μl, 0.450 mmol) at room temperature under nitrogen for 1 h. The reaction was quenched with hydrochloric acid (450 μl, 0.450 mmol). Solvent was removed under reduced pressure and residue was freeze dried overnight. Product contains 1.5 equivalents of sodium chloride: LC/MS: [(M+1)]+=220.9.

1. customSolvent was removed under reduced pressure and residue
2. customdried overnight