Hydrochloric Acid → HCID 89618840, compound

HRID 1502171Notes

Reaction equation

HRID 1502171 reaction equation
[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([NH:12]C(=O)OC(C)(C)C)=[N:10][CH:11]=2)[CH:5]=[N:4][N:3]=[N:2]1.[ClH:20].O1CCOCC1>C(Cl)Cl>[ClH:20].[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([NH2:12])=[N:10][CH:11]=2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 89619100HCID 89619100, compound

Product 1

HCID 89618840HCID 89618840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 5-(1H-tetrazol-1-yl)pyridin-2-ylcarbamate (300 mg, 1.14 mmol) was dissolved in DCM (2 mL), followed by addition of 4 M HCl in dioxane (2.86 mL, 11.4 mmol). The mixture was stirred at RT for 4 hours, then concentrated to give title compound. LC/MS: [(M+1)]+=163.20.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-e7bc90844b3f49739f90f0087c0e2b22
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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