Diethyl Malonate → Dimethyl malonate

HRID 1502206Notes

Reaction equation

HRID 1502206 reaction equation
[C:1]([O:9][CH2:10]C)(=[O:8])[CH2:2][C:3]([O:5][CH2:6]C)=[O:4]>CCC(=O)CC>[C:1]([O:9][CH3:10])(=[O:8])[CH2:2][C:3]([O:5][CH3:6])=[O:4]

Participants

3

Reactant 1

HCID 7761Diethyl Malonate

Product 1

HCID 7943Dimethyl malonateYield 29%

Reagents, catalysts & solvents 1

HCID 7288Ethyl ketoneSolvent

Procedure

The target product was obtained in the same manner as in Production Example 1, except that 3-pentanone was used instead of benzaldehyde, and diethyl malonate was used instead of dimethyl malonate (yield: 29%). The 1H-NMR spectrum of the reaction product obtained using a nuclear magnetic resonance spectrometer was analyzed, and it was found that the chemical shift values were 1.09 (t, 6H), 2.27 (t, 6H), 2.36 (q, 4H), 4.20 (q, 4H). It was thus confirmed that the product was diethyl(1-ethylpropylidene)malonate. The purity of the resulting diethyl(1-ethylpropylidene)malonate determined by liquid chromatography was 100%.

Sources & evidence

ORD record
ord-17357159c5794d33b48196aa2dedb587
Source dataset
uspto-grants-2015_12
Patent number
US09206265B2

Reaction notes

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