Sodium Hydroxide → HCID 69230210, compound

HRID 1502323Notes

Reaction equation

HRID 1502323 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]1)[C:5]([O:7]C)=[O:6].[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH3:19])[CH2:17][CH2:18]1)[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67974924HCID 67974924, compound

Product 1

HCID 69230210HCID 69230210, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl 3-chloro-4-((4-methylpiperazin-1-yl)methyl)benzoate (270 mg, 0.96 mmol) in tetrahydrofuran was added to an aqueous sodium hydroxide solution (6 M, 1.5 mL) and the mixture was stirred at room temperature for 5 hours. The organic solvent was removed under reduced pressure and the residue was acidified with aqueous HCl until a white solid formed. The mixture was lyophilized to give a white solid (contained salt). LCMS (ESI): RT (min)=0.819, M+H+=268.8, method=B.

Workup

  1. customThe organic solvent was removed under reduced pressure
  2. customformed
  3. customto give a white solid (contained salt)
  4. customRT (min)=0.819, M+H+=268.8, method=B

Sources & evidence

ORD record
ord-c82dce3d2d4244e28dfac8d516a08b7b
Source dataset
uspto-grants-2015_12
Patent number
US09206175B2

Reaction notes

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