反应详情

温度

60 °C

2-Methoxy-4-(2′,2′,2′-tris(octadecyloxymethyl)ethoxy)benzaldehyde (288 mg, 280 μmol) was dissolved in THF (3 ml), methanol (0.3 ml) and sodium borohydride (31.8 mg, 841 μmol) were added, and the mixture was stirred at 60° C. for 2 hr. The reaction mixture was cooled to room temperature, 1N hydrochloric acid (5 ml) and chloroform (5 ml) were added, and the mixture was stirred. The aqueous layer was removed, and the organic layer was further washed twice with purified water (5 ml). The organic layer was evaporated under reduced pressure, and the residue was azeotropically distilled with acetonitrile and dried in vacuo to give 2-methoxy-4-(2′,2′,2′-tris(octadecyloxymethyl)ethoxy)benzyl alcohol.

1. temperatureThe reaction mixture was cooled to room temperature
2. stirringthe mixture was stirred
3. customThe aqueous layer was removed
4. washthe organic layer was further washed twice with purified water (5 ml)
5. customThe organic layer was evaporated under reduced pressure
6. distillationthe residue was azeotropically distilled with acetonitrile
7. customdried in vacuo