Hydrochloric Acid → HCID 131734311, compound

HRID 1502575Notes

Reaction equation

HRID 1502575 reaction equation
CN(C=[C:5]1[C:9](=[O:10])[N:8]([C:11](OC(C)(C)C)=[O:12])[CH:7]2[C:18]3[C:23]([CH2:24][CH:6]12)=[CH:22][CH:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=3)C.Cl>O1CCOCC1.C(OCC)(=O)C>[OH:10][CH:9]=[C:5]1[C:11](=[O:12])[NH:8][CH:7]2[C:18]3[C:23]([CH2:24][CH:6]12)=[CH:22][CH:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=3

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89618107HCID 89618107, compound

Product 1

HCID 131734311HCID 131734311, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 7-methyl 3-(dimethylaminomethylene)-2-oxo-4,8b-dihydro-3aH-indeno[1,2-b]pyrrole-1,7-dicarboxylate (610 mg, 1.6 mmol) in dioxane (20 mL) was added HCl (36%, 2.9 mL, 32 mmol). The solution was stirred overnight at room temperature. The solution was diluted with ethyl acetate and washed twice with water, brine, dried over magnesium sulphate and concentrated to give title compound (0.300 g, 73%). This compound was used without extra purification. LC/MS (method B) RT: 0.65 min; ES−: 258, M−H+.

Workup

  1. washwashed twice with water, brine
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-c65ead892adf46a2b09c7c165b0747e6
Source dataset
uspto-grants-2015_12
Patent number
US09210929B2

Reaction notes

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