反应详情

温度

150 °C

A microwave vial was charged with 2-amino-3-bromopyridine (0.5 g, 2.9 mmol), phenylboronic acid (0.52 g, 4.3 mmol), sodium bicarbonate (0.31 g, 2.9 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.1 g, 0.14 mmol), dioxane (5 mL) and water (1 mL). The vial was capped, and the reaction mixture was heated at 150° C. for 10 min. The reaction mixture was then cooled, quenched with water (10 mL), and extracted twice with ethyl acetate. The combined organic phases were dried (MgSO4) and concentrated to leave a black oil. The crude product was purified by chromatography on silica gel using 10-40% ethyl acetate/hexanes as eluant to provide the title compound as a white solid (0.35 g).

1. customThe vial was capped
2. temperatureThe reaction mixture was then cooled
3. customquenched with water (10 mL)
4. extractionextracted twice with ethyl acetate
5. dry with materialThe combined organic phases were dried (MgSO4)
6. concentrationconcentrated
7. customto leave a black oil
8. customThe crude product was purified by chromatography on silica gel using 10-40% ethyl acetate/hexanes as eluant