Hydrochloric Acid → Sodium hydroxide rebamipide

HRID 1502602Notes

Reaction equation

HRID 1502602 reaction equation
Cl.[OH-].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1>O>[OH-:13].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5042RebamipideHCID 14798Sodium Hydroxide2×

Product 1

HCID 68327531Sodium hydroxide rebamipide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

24 ML of 10 N hydrochloric acid (2.8.4 g, 0.24 mol), 136 mL of purified water, and 400 mL of an aqueous solution containing 10% (w/v) HPMC (TC-5E) were mixed to prepare a hydrochloric acid-HPMC (TC-5E) solution. To 1400 mL of an aqueous solution of sodium hydroxide which was prepared by adding purified water to 8.8 g of sodium hydroxide (0.22 mol), 40 g of rebamipide (0.108 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Workup

  1. additionwere mixed
  2. additionby adding
  3. additionwas added
  4. dissolutiondissolved
  5. temperaturewith heating

Sources & evidence

ORD record
ord-49589992ab724d9aa42277762247d0c0
Source dataset
uspto-grants-2015_12
Patent number
US09211254B2

Reaction notes

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