HRID1502636

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID297

Methane

CH4

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCCCCCOC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)cc1

HCID178427497

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCCCCCOC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)O)cc1

HCID178427496

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

103.6 mg (0.16 mmol) of 1-benzyl 5-(6-(3-tosylguanidino)hexyl) 2-(tert-butoxycarbonylamino)pentanedioate under nitrogen in MeOH. A few mg of 10% Palladium over activated charcoal were added. 3 vacuo hydrogen flush were done before stirring vigorously the reaction under a H2 atmosphere for 2 days. The reaction was filtered over celite and the solvent evaporated to give 74.4 mg of a colorless oil (yield=86%).

WORKUP

后处理

custom3 vacuo hydrogen flush
customthe reaction under a H2 atmosphere for 2 days
filtrationThe reaction was filtered over celite
customthe solvent evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-319e3de95cd8471a9d48253bbd3df07c
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09211340B2
来源说明: uspto-grants-2015_12

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:20][CH2:21][C:22]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]([NH:34][S:35]([C:38]1[CH:44]=[CH:43][C:41]([CH3:42])=[CH:40][CH:39]=1)(=[O:37])=[O:36])=[NH:33])=[O:23])[C:10]([O:12]CC1C=CC=CC=1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C>CO.[Pd]>[NH:33]=[C:32]([NH:34][S:35]([C:38]1[CH:39]=[CH:40][C:41]([CH3:42])=[CH:43][CH:44]=1)(=[O:36])=[O:37])[NH:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][O:24][C:22](=[O:23])[CH2:21][CH2:20][CH:9]([C:10]([OH:12])=[O:11])[NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2]