3,3,3-Trifluoropropylamine → HCID 86675154, compound

HRID 1503691Notes

Reaction equation

HRID 1503691 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]([C:23]([F:26])([F:25])[F:24])/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[C:18](=O)[CH2:17][CH2:16]3)[CH:5]=[C:6]([Cl:9])[C:7]=1[F:8].[F:27][C:28]([F:33])([F:32])[CH2:29][CH2:30][NH2:31].C([BH3-])#N.[Na+]>ClCCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]([C:23]([F:26])([F:25])[F:24])/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[CH:18]([NH:31][CH2:30][CH2:29][C:28]([F:33])([F:32])[F:27])[CH2:17][CH2:16]3)[CH:5]=[C:6]([Cl:9])[C:7]=1[F:8]

Participants

5

Reactant 3

HCID 100013,3,3-TrifluoropropylamineHCID 5003444Sodium cyanoborohydrideHCID 86675155HCID 86675155, compound

Product 1

HCID 86675154HCID 86675154, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent2×

Procedure

To a stirred solution of (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2,3-dihydro-1H-inden-1-one (0.15 g, 0.35 mmol) in DCE (10 mL), was added trifluoropropyl amine (0.048 g, 0.42 mmol) and sodium cyanoborohydride (0.055 g, 0.875 mmol) in cooling and the reaction mixture was stirred at room temperature for 16 h. The reaction mixture was diluted with DCE, was washed with water and brine and dried over anhydrous sodium sulfate. Concentration under reduced pressure gave the crude compound, which was purified by flash column chromatography (SiO2, 100-200 mesh; 10-15% EtOAc in petroleum ether) to afford the title compound as a colorless gummy material (0.042 g, 24%): 1H NMR (400 MHz, CDCl3) δ 7.38-7.20 (m, 5H), 6.62 (d, J=16.0 Hz, 1H), 6.34 (dd, J=16.0, 8.0 Hz, 1H), 5.83 (br, 1H), 5.52 (m, 1H), 4.12 (m, 1H), 3.02 (m, 3H), 2.82 (m, 1H), 2.50 (m, 2H), 1.82 (m, 1H), 1.42 (m, 1H); ESIMS m/z 497.98 ([M−H]−); IR (thin film) 3027, 1654, 815 cm−1.

Workup

  1. temperaturein cooling
  2. washwas washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationConcentration under reduced pressure
  5. customgave the crude compound, which
  6. customwas purified by flash column chromatography (SiO2, 100-200 mesh; 10-15% EtOAc in petroleum ether)

Sources & evidence

ORD record
ord-fc3b34deec2f489aa44c141d66d3fde2
Source dataset
uspto-grants-2015_12
Patent number
US09212164B2

Reaction notes

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