反应详情

A dry 50 mL 3 neck round bottom flask was charged with tert-butyl (1-(methoxycarbamoyl)cyclopropyl)carbamate (0.82 g, 3.56 mmol) and 20 mL of dry DMF. The reaction mixture was cooled in an ice-water bath and 60% NaH (0.16 g, 3.92 mmol) was added in one portion. The reaction mixture was stirred at RT for 1.5 h after which time, 2,2,2-trifluoroethyl trifluoromethanesulfonate (0.87 g, 3.74 mmol) was added neat drop wise and the resulting reaction mixture was stirred at RT for 18 h. The reaction mixture was added to H2O and extracted 3× with ether. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to give 0.92 g of crude product as a white solid. This material was taken up in 5 mL of DCM and cooled in an ice water bath. 2M HCl in ether (4 mL) was added and the reaction mixture was allowed to warm toward RT and stirred for 18 h. The reaction mixture was evaporated to give a solid. This material was washed several times with 10% ether/hex to afford 0.70 g of the title compound. This material was carried forward without further purification.

1. temperatureThe reaction mixture was cooled in an ice-water bath
2. additionwas added neat drop wise
3. customthe resulting reaction mixture
4. extractionextracted 3× with ether
5. washThe organic layer was washed with brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated
9. customto give 0.92 g of crude product as a white solid
10. temperaturecooled in an ice water bath
11. temperatureto warm toward RT
12. stirringstirred for 18 h
13. customThe reaction mixture was evaporated
14. customto give a solid
15. washThis material was washed several times with 10% ether/hex