Water → HCID 70558051, compound

HRID 1503809Notes

Reaction equation

HRID 1503809 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]=2[O:24][CH3:25])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].[OH-].[NH4+:27].O>CS(C)=O>[NH2:27][C:9]1[N:8]=[C:7]([S:11][CH3:12])[N:6]=[C:5]([NH:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]=2[O:24][CH3:25])[C:4]=1[C:1](=[O:3])[NH2:2]

Participants

5

Reactant 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 86725371HCID 86725371, compound

Product 1

HCID 70558051HCID 70558051, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of the product of Example 10A (1.3 g, 3.4 mmol) in dimethylsulfoxide (50 mL) was added ammonium hydroxide (5.2 mL, 34 mmol). The mixture was heated to 100° C. for 4 hours and was allowed to cool to ambient temperature. Water (50 mL) was added and the precipitate was filtered and washed with ethanol (20 mL) to give the title compound. MS: 364 (M+H+).

Workup

  1. temperatureto cool to ambient temperature
  2. filtrationthe precipitate was filtered
  3. washwashed with ethanol (20 mL)

Sources & evidence

ORD record
ord-e729f65787cf4b3da97c30eb08443c95
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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