Hydrazine hydrate (1:1) → HCID 70558049, compound

HRID 1503811Notes

Reaction equation

HRID 1503811 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]=2[O:24][CH2:25]C)=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].O.[NH2:28][NH2:29]>O1CCCC1>[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]=2[O:24][CH3:25])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1[NH:28][NH2:29])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86725372HCID 86725372, compound

Product 1

HCID 70558049HCID 70558049, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the product of Example 11A (1.2 g, 3.1 mmol) in tetrahydrofuran (400 mL) was added hydrazine hydrate (550 mg, 9.4 mmol) and the mixture was stirred at ambient temperature for 12 hours. After concentration, the residue was washed with methanol and dried under vacuum to give the title compound, which was used in the next step without further purification. MS: 379 (M+H+).

Workup

  1. concentrationAfter concentration
  2. washthe residue was washed with methanol
  3. customdried under vacuum

Sources & evidence

ORD record
ord-3c580aa8bb5f400b97cf8d0591786f54
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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