Oxalyl chloride → 3-methoxy-4-nitro-benzoyl Chloride

HRID 1503853Notes

Reaction equation

HRID 1503853 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[C:6](O)=[O:7].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[C:6]([Cl:18])=[O:7]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 787643-Methoxy-4-nitrobenzoic acid

Product 1

HCID 111276553-methoxy-4-nitro-benzoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-methoxy-4-nitrobenzoic acid (5.7 g, 30 mmol) in dichloromethane (100 mL) and N,N-dimethylformamide (5 mL) at 0° C. was added slowly oxalyl chloride (5.08 mL, 60 mmol). After stirring for 2 hours, the mixture was concentrated and the residue was used without further purification.

Workup

  1. concentrationthe mixture was concentrated
  2. customthe residue was used without further purification

Sources & evidence

ORD record
ord-39abce92e7f34e88986c889e7e6d03f3
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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