反应详情

To a mixture of 4-bromo-2-(trifluoromethoxy)aniline (5 g, 19.53 mmol) and potassium carbonate (8.09 g, 58.89 mmol) in acetonitrile (200 mL) was added (bromomethyl)benzene (6.96 mL, 58.59 mmol) and the mixture was refluxed for 20 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 5/1 petroleum ether/ethyl acetate to give the title compound. MS: 436 (M+H+)

1. temperaturethe mixture was refluxed for 20 hours
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by flash chromatography on silica gel (200-300 mesh)
5. washeluting with 5/1 petroleum ether/ethyl acetate