反应详情

Potassium carbonate (0.829 g) was dissolved in acetonitrile(10 ml) and water(10 ml), and 6-hydroxy-2-methoxyquinoline(0.875 g) and 1-chloro-3-bromopropane(1.48 ml) was added thereto, and the mixture was stirred while heating under reflux for 4 hours. The reaction mixture was condensed under reduced pressure. Water was added to the residue, followed by extraction using ethyl acetate. The organic layer was dried with sodium sulfate, and was condensed under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1). The purified product was condensed to dryness under reduced pressure to give the title compound(1.107 g) as a white powder.

1. temperaturewhile heating
2. temperatureunder reflux for 4 hours
3. customcondensed under reduced pressure
4. extractionfollowed by extraction
5. dry with materialThe organic layer was dried with sodium sulfate
6. customcondensed under reduced pressure
7. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1)
8. customcondensed to dryness under reduced pressure