反应详情

温度

80 °C

6-(3-Amino-propoxy)-1-methyl-1H-quinolin-2-one(232 mg), 4-bromo-1-methoxy-isoquinoline(286 mg), palladium acetate (II) (22 mg), xantphos (558 mg), and sodium t-butoxide(192 mg) were added to dioxane(10 ml). The mixture was heated at 80° C. for overnight under argon atmosphere. The reaction liquid was cooled to room temperature. Water was added to the reaction mixture, and followed by celite filtration. The filtrate was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate. The filtrate was condensed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate: hexane=2:1→1:0). The purified product was condensed under reduced pressure to give the title compound(99 mg) as a brown amorphous solid.

1. customThe reaction liquid
2. temperaturewas cooled to room temperature
3. filtrationfollowed by celite filtration
4. extractionThe filtrate was extracted with dichloromethane
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. customcondensed under reduced pressure
7. customthe residue was purified by silica gel column chromatography (ethyl acetate: hexane=2:1→1:0)
8. customcondensed under reduced pressure