反应详情

5-(1H-Benzimidazol-2-ylmethyl)-2-methyl-5H-furo[3,2-c]pyridine-4-one(0.75 g), 1-bromo-3-chloropropane(1.3 ml), and potassium carbonate(0.95 g) were added to 50% hydrous acetonitrile(16 ml). The mixture was heated overnight under reflux. The reaction mixture was cooled to room temperature. Water was added thereto, followed by extraction by ethyl acetate. The organic layer was dried over sodium sulfate, and condensed under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1→0:1). The purified product was condensed to dryness under reduced pressure to give the title compound(0.18 g) as a colorless oily matter.

1. temperatureThe mixture was heated overnight
2. temperatureunder reflux
3. extractionfollowed by extraction by ethyl acetate
4. dry with materialThe organic layer was dried over sodium sulfate, and condensed under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1→0:1)
6. customcondensed to dryness under reduced pressure