Hydrochloric Acid → 1-ethyl-3,3,5-trimethyl-7-(3-((3-(1-oxoisoquinolin-2(2H)-yl)propyl)(pyridin-4-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione dihydrochloride

HRID 1504237Notes

Reaction equation

HRID 1504237 reaction equation
[ClH:1].[CH2:2]([N:4]1[C:10](=[O:11])[C:9]([CH3:13])([CH3:12])[C:8](=[O:14])[N:7]([CH3:15])[C:6]2[CH:16]=[C:17]([O:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:32][CH2:33][CH2:34][N:35]3[CH:44]=[CH:43][C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])[CH2:25][C:26]3[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=3)[CH:18]=[CH:19][C:5]1=2)[CH3:3]>C(OCC)(=O)C>[ClH:1].[ClH:1].[CH2:2]([N:4]1[C:10](=[O:11])[C:9]([CH3:13])([CH3:12])[C:8](=[O:14])[N:7]([CH3:15])[C:6]2[CH:16]=[C:17]([O:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:32][CH2:33][CH2:34][N:35]3[CH:44]=[CH:43][C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])[CH2:25][C:26]3[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=3)[CH:18]=[CH:19][C:5]1=2)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 901135391-ethyl-3,3,5-trimethyl-7-(3-((3-(1-oxoisoquinolin-2(2H)-yl)propy 1) (pyridin-4-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

Product 1

HCID 901135451-ethyl-3,3,5-trimethyl-7-(3-((3-(1-oxoisoquinolin-2(2H)-yl)propyl)(pyridin-4-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 4N-hydrogen chloride in ethyl acetate solution(0.3 ml) was added to an ethyl acetate solution (3 ml) of 1-ethyl-3,3,5-trimethyl-7-(3-((3-(1-oxoisoquinolin-2(2H)-yl)propyl)(pyridin-4-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (159 mg), and the mixture was stirred at room temperature for two hours. The reaction mixture was condensed under reduced pressure to give the title compound(178 mg) as a amorphous solid.

Workup

  1. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-1d93b59745da48448ef3ca8461793d15
Source dataset
uspto-grants-2015_12
Patent number
US09212187B2

Reaction notes

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