4,4-Difluorocyclohexan-1-ol → HCID 178506004, compound

HRID 1504397Notes

Reaction equation

HRID 1504397 reaction equation
[I-:1].[Zn+2:2].[I-].[F:4][C:5]1([F:12])[CH2:10][CH2:9][CH:8](O)[CH2:7][CH2:6]1>C1COCC1>[I-:1].[F:4][C:5]1([F:12])[CH2:10][CH2:9][CH:8]([Zn+:2])[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 5463004,4-Difluorocyclohexan-1-olHCID 9883512zinc(II)iodide

Product 1

HCID 178506004HCID 178506004, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in an analogous manner to tetrahydro-2H-pyran-4-yl)zinc(II) iodide except that 4,4-difluorocyclohexanol (Affinity Chemicals) was used instead of tetrahydro-2H-pyran-4-ol in Step 1 to afford a 0.26 M solution of (4,4-difluorocyclohexyl)zinc(II) iodide in THF.

Sources & evidence

ORD record
ord-b276b91074cf43149f567f683956b7d8
Source dataset
uspto-grants-2015_12
Patent number
US09212182B2

Reaction notes

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