Diethyl Ether → HCID 131734333, compound

HRID 1504740Notes

Reaction equation

HRID 1504740 reaction equation
[NH2:1][C@H:2]([C:8]([NH:10][NH:11]C(OC(C)(C)C)=O)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[OH:6].[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20].C(OCC)C>C(Cl)Cl>[NH2:1][C@H:2]([C:8]([NH:10][NH2:11])=[O:9])[CH2:3][CH2:4][C:5](=[O:6])[OH:7].[F:22][C:21]([C:19]([OH:25])=[O:20])([F:24])[F:23]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6422Trifluoroacetic acidHCID 88447749HCID 88447749, compound

Product 1

HCID 131734333HCID 131734333, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EMC-Glu-NH—NH-BOC (32.4 g) and TFA (165 mL) in DCM (165 mL) was stirred at RT for 80 min after which diethyl ether (4 L) was added. The precipitated product was collected by suction filtration, washed with ether and dried yielding EMC-Glu-NH—NH2 TFA (20 g).

Workup

  1. additionwas added
  2. filtrationThe precipitated product was collected by suction filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-1c6aeaf38b834e2884a0292faebb1e10
Source dataset
uspto-grants-2015_12
Patent number
US09216228B2

Reaction notes

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