反应详情

To a solution of 1,2-dibromo-6-chlorohexan-3-one in isopropanol (80% solution in water, 30 mL) at ambient temperature was added hydrazine hydrate (8.4 g, 170 mmol). After 16 hours, the reaction mixture was quenched with water (15 mL) and extracted with ethyl acetate (3×30 mL). The organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 3-(3-chloropropyl)-1H-pyrazole, which was used without further purification.

1. customthe reaction mixture was quenched with water (15 mL)
2. extractionextracted with ethyl acetate (3×30 mL)
3. dry with materialThe organic layers were dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure