Trifluoroacetic acid → HCID 58497933, compound

HRID 1505280Notes

Reaction equation

HRID 1505280 reaction equation
C([O:5][C:6]([C:8]1[O:12][N:11]=[C:10]([C:13]2[CH2:17][C:16]([C:22]3[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([Cl:29])[CH:23]=3)([C:18]([F:21])([F:20])[F:19])[O:15][N:14]=2)[CH:9]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>>[Cl:28][C:26]1[CH:27]=[C:22]([C:16]2([C:18]([F:20])([F:19])[F:21])[O:15][N:14]=[C:13]([C:10]3[CH:9]=[C:8]([C:6]([OH:7])=[O:5])[O:12][N:11]=3)[CH2:17]2)[CH:23]=[C:24]([Cl:29])[CH:25]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67217964HCID 67217964, compound

Product 1

HCID 58497933HCID 58497933, compoundYield 96.2%

Procedure

Similarly to example 14.2, the 5′-(3,5-Dichloro-phenyl)-5′-trifluoromethyl-4′,5′-dihydro-[3,3′]biisoxazolyl-5-carboxylic acid tert-butyl ester (393 mg) was deprotected with trifluoroacetic acid to give the 5′-(3,5-Dichloro-phenyl)-5′-trifluoromethyl-4′,5′-dihydro-[3,3′]biisoxazolyl-5-carboxylic acid (331 mg) as a white solid. 1H-NMR (CDCl3, 400 MHz): 7.65 (bs, 1H) 7.46 (m, 2H), 7.44-7.42 (m, 2H), 4.17 (d, 1H), 3.81 (d, 1H).

Sources & evidence

ORD record
ord-b995315cb7234a3d974a1e4484c96eef
Source dataset
uspto-grants-2015_12
Patent number
US09216973B2

Reaction notes

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