Hydrochloric Acid → HCID 68042529, compound

HRID 1505488Notes

Reaction equation

HRID 1505488 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([NH:15][S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[C:9]=1[F:22])(C)(C)C.Cl>C(OC(=O)C)C>[NH2:7][C:8]1[C:9]([F:22])=[C:10]([NH:15][S:16]([CH:19]([CH3:20])[CH3:21])(=[O:18])=[O:17])[CH:11]=[CH:12][C:13]=1[F:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131734351HCID 131734351, compound

Product 1

HCID 68042529HCID 68042529, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The tert-butyl-2,6-difluoro-3-(1-methylethylsulfonamido)phenylcarbamate (100 mg, 0.3 mmol) prepared at Step 4 was added into ethylacetate solvent and, hydrogen chloride (4M solution in 1,4-dioxane) was applied and stirred at room temperature for 5 hours. After the reaction, the solvent was concentrated and vacuum filtrated, and the remaining solid was washed with diethyl ether and hexane and dried, so that 65 mg of the target compound, N-(3-amino-2,4-difluorophenyl)propane-2-sulfonamide (percentage yield: 91%), was obtained.

Workup

  1. customAfter the reaction
  2. concentrationthe solvent was concentrated
  3. filtrationvacuum filtrated
  4. washthe remaining solid was washed with diethyl ether and hexane

Sources & evidence

ORD record
ord-571efd8945cd40b7b3f5436d0ba509d8
Source dataset
uspto-grants-2015_12
Patent number
US09216981B2

Reaction notes

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